keywords: Dannettiatripetala, 2,2-diphenyl-picrlhydrazyl (DPPH), scavenging activities, lipid profile
Dennettiatripetala belongs to the family Annonaceae. The aqueous and n-Hexane extract were screened for the presence of phenols, flavonoids and vitamin C and the 2,2-diphenyl-picrlhydrazyl (DPPH) radical scavenging activities of the extracts were also determined. Twenty five Wistar rats of either sex, weighing 130-140g, were used for this study. The animals were grouped into five Groups: A, B, C, D and E of five animals each. The control group animals were served single oral daily doses of normal saline, while the experimental groups B, C, D and E received 1.0, 1.5, 2.0 and 2.5 mg/kg b.w of the aqueous extract for 10 days, respectively. Twenty four hours after the last administration, the animals were sacrificed under chloroform anaesthesia. Determination of the concentrations of total proteins, cholesterol, LDL, TAG and HDL were by standard methods. The results showed that the extract caused a dose dependent significant (p < 0.05) increase in the body weight of the test animals when compared with the control group A, but the weight of the liver and kidney did not increase or decrease significantly (p > 0.05). Both extracts contain phenols, flavonoids and vitamin C. However, the concentration of these phytochemicals were more in the aqueous extract, also the aqueous extract exhibited radical scavenging activity than the n-Hexane extract. The treatment of the rats with the aqueous extract produced a dose dependent significant (p < 0.05) increase in the concentration of total proteins and HDL. The treatment significantly (p < 0.05) and in a dose dependent manner decreased the concentration of cholesterol, TAG and LDL. The phenolic content of the extract could be responsible for the radical scavenging activity; extract has lipid lowering properties, which may be enhanced in the management of lipid related disorders.
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