keywords: Amoxicillin, antibiotic, brand, ciprofloxacin, erythromycin, S. aureus
This study is to compare the effectiveness of three (3) different commercial brands of antibiotics (the antibiotics selected for the comparison include: Amoxicillin, Ciprofloxacin and Erythromycin) against the standard (NCTC 8854) and two (2) clinical Staphylococcus aureus isolated from wounds of two different patients attending Bethel Hospital Wukari, Taraba State. The brands of antibiotics selected and used for this work were marked as Brand 1, 2 and 3. The methods of assay used were, Dilution Test for the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) following these concentrations: 1, 10-1, 10-2, 10-3, 10-4 and 10-5 mg/ml along with positive and negative control for all the antibiotics. Disc Diffusion Test was carried out to determine the Antibiotic Susceptibility Test (AST). The discs used were locally produced with the concentration of 1 mg/ml for each of the antibiotics. Brand 3 antibiotics were found to be the most effective against all the isolates with MIC as low as 10-3 mg/ml and MBC of 10-1 mg/ml. There was no much differences in the AST of the different brands. Ciprofloxacin showed up as the antibiotic with better MIC and MBC. Therefore, in comparing the effectiveness of the three (3) different commercial brands of antibiotics; the Brand 3 is the most effective brand while ciprofloxacin is the most effective antibiotic.
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