keywords: Bacterial pathogens, antibiotics, resistance patterns, nosocomial infections, susceptibility patterns
Nosocomial bacterial pathogens are bacteria that are responsible for infections acquired from hospitals. The infections could be from an inanimate objects or substances recently contaminated from another human source. Bacteria encountered in the study were isolated on bacteriological media, their biochemical tests were carried out and the antibiotic susceptibility pattern of the bacterial isolates was determined by disc diffusion method. Nosocomial bacteria, particularly, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus species, Escherichia coli and Klebsiella spp are the predominant pathogens associated with hospital acquired infections. Hence, the aim of the study is to determine the efficacy of antibiotics on bacterial pathogens associated with nosocomial infections in some selected hospitals from Makurdi, Nigeria. The samples were collected from different surfaces of the selected hospitals environment, isolated and characterized using different cultural, morphological and biochemical tests before carrying out antibiotic susceptibility testing and in-vitro determination of antibiotic susceptibility. The efficacy of antibiotic susceptibility pattern on Staphylococcus speciesshows highest level of antibiotic sensitivity which were demonstrated by Cloxacillin and Ofloxacin with 50%; Augumentin and Cefuroxime with 40%, Gentamicin (30%), Erythromycin (20%) and least sensitivity with Ceftriazone (10%) while Ceftazidime has the highest resistance recorded 0% sensitivity. Escherichia coli has the highest sensitivity on Ceftazidime having 81.8% and Gentamicin 63.6%, Ofloxacin also displayed a high level of sensitivity to isolates tested with 63.6% sensitive, follow by Cefuroxime (45.5%). Therefore, in-vitro antibiotics sensitivity testing further reveals that Pseudomonas aeruginosa and Klebsiella strains had considerable resistance to many antibiotic employed. Therefore, information on resistance patterns of bacterial pathogens evolved will assist in making improvement in management of nosocomial infections.
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