FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Binding concentration, disintegration, Paracetamol, strength friability
Natural gums are economical, easily available and have been found useful as binders in tablet formulations. In the present study, A. congensis was studied and employed as a binder in drug formulation with Paracetamol as a model drug at concentrations of 1.0-5.0% w/w and gelatin mp (standard binder). Paracetamol tablets were prepared by wet granulation technique using A. congensis gum (ACG) as a tablet binder. The properties of the prepared tablets were evaluated for crushing strength, friability, disintegration and dissolution time of the tablets. Studies showed that increase in binding concentration of ACG increases the crushing strength which ranges between 25±2.64 to 120.55±1.64 which are comparable with the standard binder and the disintegration time ranging from 1.55±0.6-17.58±1.46. Also, there was an increase in the dissolution rate at t50(23.20±1.46 to 100.50±0.24) and t90(73.20±1.64 to 260.4±3.1) of Paracetamol tablets formulated with ACG compared to the standard binder. The studies also showed that increase in binding concentration of ACG, decreases the percentage friability of the Paracetamol tablets with range between 1.22±0.04 to 0.60±0.04 compared to the standard binder (1.10± 0.08 to 0.78±0.06). Results obtained indicated that there is a significant difference between ACG and gelatin (p<0.05) as a binder in Paracetamol tablets, hence should be explored and used as a binder in drug formulations.
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