keywords: Binding concentration, disintegration, Paracetamol, strength friability
Natural gums are economical, easily available and have been found useful as binders in tablet formulations. In the present study, A. congensis was studied and employed as a binder in drug formulation with Paracetamol as a model drug at concentrations of 1.0-5.0% w/w and gelatin mp (standard binder). Paracetamol tablets were prepared by wet granulation technique using A. congensis gum (ACG) as a tablet binder. The properties of the prepared tablets were evaluated for crushing strength, friability, disintegration and dissolution time of the tablets. Studies showed that increase in binding concentration of ACG increases the crushing strength which ranges between 25±2.64 to 120.55±1.64 which are comparable with the standard binder and the disintegration time ranging from 1.55±0.6-17.58±1.46. Also, there was an increase in the dissolution rate at t50(23.20±1.46 to 100.50±0.24) and t90(73.20±1.64 to 260.4±3.1) of Paracetamol tablets formulated with ACG compared to the standard binder. The studies also showed that increase in binding concentration of ACG, decreases the percentage friability of the Paracetamol tablets with range between 1.22±0.04 to 0.60±0.04 compared to the standard binder (1.10± 0.08 to 0.78±0.06). Results obtained indicated that there is a significant difference between ACG and gelatin (p<0.05) as a binder in Paracetamol tablets, hence should be explored and used as a binder in drug formulations.
Patel DM, Prajapat DG & Patel NM 2007. Seed mucilage from Ocimum americanum as disintegrant in tablets: Separation and evaluation. Indian J. Pharmac. Sci., 69: 431-34. Grössl M, Harrison SK & Kenndler E 2005. Characterization of natural polysaccharides (plant gums) used as binding media for artistic and historic works by capillary zone electrophoresis. J. Chromat., 1077(1): 80 – 89. Ibrahim MA, Dawes VH & Bangudu AB 2000. Evaluation of Cissus populnea polymer as a matrix former for controlled drug release. J. Phytomed. Therap., v.5: 23-32, Sinha VR & Kumaria R 2012. Binders for colon specific drug delivery: an in vitro evaluation. Int. J. Pharm. v.249: 23- 31. Emeje M, Nwabunike P, Isimi C, Fortunak J, Mitchell JW, Byrn S, Kunle O & Ofoefule S 2009. Isolation, characterization and formulation properties of a new plant gum obtained from Cissus refescence. Afr. J. Pharm. Pharmacol., v.3: 16-23. IPEC – PQG Good Manufacturing Practices. 2006. Guide for Pharmaceutical Excipients. Eichie FE & Amalime AE 2007. Evaluation of the binder effects of the gum mucilage’s of cissus populnea and acassia senegal on the mechanical properties of paracetamol tablets. Afr J Biotechnol., 6(19): 2208-2211. Iwuagwu MA 1991. Evaluation of Some Soluble Starches as Lubricants in the Formulation of Compressed Tablet, World Pharm. J., 8(1): 19-23. Tsige G & Alexander SN 1993. Evaluation starch obtained from Esente ventricosum as a binder and disintegrant for compressed tablets. J. Pharm. Pharmacol., 45(307): 317-320. Nasipuri RN, Igwilo CI, Brown SA & Kunle OO 1999. Mucilage from Abelmuschus esculentus fruits – a potential pharmaceutical raw material III: suspending properties. J. Pharm Res. Dev., 2: 121 – 130. Odeku OA & Itiola OA 1998. Evaluation of khaya gum as a binder in a paracetamol tablet Formulation. Pharm. Pharmacol. Commun., 33(3): 263-68. Odeku OA & Itiola OA 2005. Characterization of Khaya gum as a binder in a paracetamol tablet formulation. Drug Dev. Ind. Pharm., 28(3): 329-337. Kalu VD, Odeniyi MA & Jaiyeoba KT 2007. Matrix properties of a new plant gum in controlled drug delivery. Arch. Pharm. Res., 30(7): 884-889. Ibezim EC, Ofoefule SI, Omeje EO, Onyishi VI & Odoh UE 2008. The role of ginger starch as a binder in acetaminophen tablets, Scientific Research & Essay, 3(2): 046-050. Burkill HM 1985. The useful plants of West Tropical Africa. 2nd Edition. Volume 1, Families A–D. Royal Botanic Gardens, Kew, Richmond, United Kingdom, p. 960. Sidiyasa K 1998. Taxonomy, phylogeny, and wood anatomy of Alstonia (Apocynaceae). Blumea Supplement 11. Rijks herbarium/Hortus Botanicus, Leiden University, Leiden, Netherlands, 230 pp. Neuwinger HD 2000. African traditional medicine: a dictionary of plant use and applications. Medpharm Scientific, Stuttgart, Germany, 589pp. World Agroforestry Centre, undated. Agroforestree Database. [Internet] World Agroforestry Centre (ICRAF), Nairobi, Kenya. http://www.worldagroforestry.org/ Sites/TreeDBS/ aft.asp. Accessed January 2005. British Pharmacopoeia 1998. HMSO, London, A262. Ayorinde JO, Itiola OA, Odeku OA, Odeniyi MA 2011. Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations. Brazilian J. Pharmac. Sci., 47(4). Shivanand P, Devmuravi V & Goyani M 2010. Formulation and evaluation of taste masked fast disintegrating tablets of Lisinopril. Inter. J. Pharm. Tech. Res., 2(2): 1639-1643. British Pharmacopoeia 2003. Her majesty’s Stationery Office, London. British Pharmacopoaeia 2009. The Commision Office London, 111: 6578- 6585. Odeku OA & Itiola OA 2003. Interacting variables on the tensile strength and the release properties of Paracetamol tablets. Tropical J. Pharmac. Res., 2(1): 147-153. Reza E, Mohammad A & Yousef E 2012. Assessment of Ferula gummosa gum as a binding agent in tablet formulations. Acta Poloniae Pharmaceutica ñ Drug Research, 69(2): 291–298. Odeku OA & Fell JT 2004. Evaluation of Khaya gums as a direct compressed matrix system for controlled released tablets. J. pharm. Pharmacol. 56: 1365-1370. Oluwatoyin AO 2005. Assessment of Albizia zygia gum as a binding agent in tablet formulations. Acta. Pharmacutica., 55: 263-276.