keywords: Acetaminophen, magnesium, antimicrobial, anti-inflammatory, toxicity, metal, complex
Magnesium complex of Acetaminophen was synthesized and characterized by infrared spectroscopy, UV-Visible spectroscopy, melting point, X-Ray diffraction analysis and conductivity measurements. On the basis of this study, it is proven that acetaminophen acts as a bidentate ligand coordinated to the metal ion through phenol and carbonyl oxygen atom. Antimicrobial and antifungal activities of magnesium complex and acetaminophen were determined against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeroginesa and Candida albicans. The results indicate that acetaminophen showed sensitivity against Pseudomonas aeroginesa. Magnesium complex of acetaminophen showed activity against Staphylococcus aureus, Salmonella typhi and Pseudomonas aeroginesa. The lethal dose determination (LD50) of magnesium complex was 1265 mg/kg. The complex was considered to be slightly toxic. Anti-Inflammatory activity of the synthesized complex has been carried out by paw edema method in rats. The Maximum Percentage inhibition of Magnesium complex was 18.9%.