FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Biological, anti-oxidant, Cochlospermum planchonii, Cochlospermum, IC50, scavenging
This work was aimed at evaluating the biological and anti-oxidant potential of the ethyl acetate and methanol fractions of the root of Cochlospermum planchonii and also to carryout biological activities on petroleum ether, Chloroform ethyl acetate and methanol. Chloroform gave the highest extractive value followed by methanol, petroleum ether and ethyl acetate. The antimicrobial screening of the root extracts of the plants were carried out on the following Microorganisms; Staphylococcus aureus, Escherichia Coli, Salmonella Typhi, Shigellia Dysenteric, Microsperum Canis, and Candida albicans. Klebselia pneumonia, Vibrio Cholerae and Trichophyton sp to determine their activities. The root extract showed that seven (7) of the microorganisms were sensitive to all the four extracts and two (2) were resistant to the extracts and the zone of inhibition observed for the microbes. The ethyl acetate extract show the highest zone of inhibition ranging from 24 to 28 mm and petroleum ether extract show the lowest values ranging from 16 to 18 mm. The antioxidant activities of the extracts have a high concentration which gives high percentage of DPPH inhibition with low inhibitory concentration (IC50) value, of 1.06 µg/ml and 2.61 µg/ml for Methanol and ethyl acetate extracts respectively while the standard ascorbic acid have IC50 of 107.08 µg/ml as calculated from regression equation from the graph which means that the extracts were more active than the standard ascorbic acid in antioxidant properties as compared with standard ascorbic acid.
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