Abstract

Clay minerals can accommodate polar organic compounds between their layers to form a variety of intercalated compounds; from which drugs release are potentially controllable, hence these new materials have great potential as a delivery host in the pharmaceutical field. The various powder hybrids were thoroughly mixed by wet granulation process, dried, sieved and the blends were compressed on a single punch machine. The tablets were subjected to various tests, uniformities were shown in diameters (12.45±0.01 mm), thicknesses (0.33±0.01 mm), and weights (not > 0.52±0.01 g); the varying results obtained were more pronounced in hardness, friability, disintegration, and dissolution tests. Maximum hardness measured are shown as follows: Na-MMT 8.90±0.33 KN, Kaolinite 10.60±0.33 KN and MS 8.74±0.33 KN; maximum friability reported were in the following order Na-MMT 0.40±0.01%, Kaolinite 0.20±0.01% and MS 0.46±0.01%. dissolution of tablets in 0.1M HCl and the UV absorbance at 242 nm showed varying PCM concentrations released as MS 1.17A, Na-MMT 0.71A and Kaolinite 0.40A The disintegrant physical properties of Maize-Starch were compared to Montmorillonite and Kaolinite, to ascertain the better disintegrant physical properties possessed by selected clay minerals that can be used as alternative to Maize-Starch. The objective of the present study was to formulate paracetamol (PCM) by direct compression method. The work also examines the advantageous effect of clay minerals as drug carrier for PCM, a derivative of aniline most widely used as analgesic and antipyretic drug.