keywords: Metal complexes, NSAIDs, aspirin, anti-inflammatory, ascorbic acid, antioxidant
Synthesis of Cu(II), Co(II), Ni(II), Mn(II) and Zn(II) complexes with mixed ligands Aspirin (asp) and Ascorbic acid (asc) has been carried out. The complexes were characterized by determination of physicochemical properties such as melting point, solubility, conductance, elemental analyses, magnetic susceptibility and spectroscopic analyses(UV-Visible and Infrared). The electronic spectra data are characteristic of octahedral geometry except [Zn(asp)(asc)], which is tetrahedral. The coordination to the metal ion was through the carboxylate oxygen atoms in aspirin while the carbonyl oxygen and hydroxyl oxygen of ascorbic acid serve as coordination atoms. The antioxidant studies revealed that Ni(II) and Zn(II) complexes showed the best activities with 84.2 and 89.0 percentage inhibitions respectively, which are comparable to that of the standard (ascorbic acid) with 87.0 percent inhibition. Also, the result of anti-inflammatory activity using egg albumin denaturation shows that the Co(II) and Mn(II) complexes had the best activity of 70.6 and 62.0 percentage inhibition of protein denaturation and compared favorably with the standard drug(aspirin). The derived metal complexes displayed considerable antioxidant and anti-inflammatory activities.