keywords: Antimicrobial activity, hydrazide, reflux, transition metal complex, synthesis
Complexes of isonicotinic acid hydrazide with Cu(II), Co(II) and Ni(II) have been prepared and characterized by analytical and physico-chemical techniques, such as elemental analysis, melting point and solubility studies, magnetic susceptibility and conductivity measurements, electronic and IR spectral studies. The infrared spectral studies revealed the bidentate nature of the Schiff base in the complexes; the ligand acting as neutral bidentate donor coordinating to the metal through the carbonyl O and the azomethine N. An octahedral geometry is suggestedfor all the complexes. The compounds were subjected to antimicrobial screening using serial broth dilution method and they show moderate antimicrobial activity.
Ababei LV 2012. Transition Metal Complexes with Hydrazones derived from Isonicotinic Acid Hydrazide. Ph.D. thesis. Department of Chemistry, University of Bucharest, p. 54. Amudat L 2010. Synthesis, Characterization and Biological Studies of Mixed Vitamins-Metal Complexes. Ph.D. thesis. Department of Chemistry, University of Ilorin, Nigeria. 175. Anderson RJ, Bendell DJ & Ground water PW 2004. Organic Spectroscopic Analysis, Royal Society of Chemistry, 24-27, 51-89. Casanova J, Alzuet G, Ferrer S, Borras J, Garcia-Granda S & Perez-Carreno EJ 1993. Metal complexes of sulfanilamide Derivatives Crystal structure of (Zn (sulfathiazole)2). Inorg. Biochem,.51: 689-699. Dianu ML, Angela K, Stãnicã N, Drãghici C & Popoiu M 2009. Synthesis and characterization of some tranzition metalscomplexes with glyoxal bis- isonicotinoyl hydrazone. Rev Chim-Bucharest, 60(6): 555-560. Dnyandeo MJ, Dingambar DG, Priyanka LA & Ganesh SK 2015. Efficient ultrasound synthesis and biological screening of metal complexes of N-(4-Methoxybenzylidiene) isonicotinohydrazone. World J. Pharm. Res., 5(2): 1153-1161. Kamalakev RK, Sayaji R and Biyyala SR 2015. Synthesis and Characterization and Biological Activities of Hydrazones. Int. J. Innov. Res. Sci. Eng. Technol., 4(1): 18944-18952. Nakamoto K 1992. Infrared and Raman Spectra of Inorganic and Co-ordination Compounds, 3rd edn. John Wiley and Sons, New York, p. 110. Obaleye JA, Orjiekwe CL & Edward DA 2000. 1-crotonyl-2,4 -Diaza -1,3-butanedione metal complexes: Synthesis and spectroscopic investigations.Synth React Inorg. M., 30(4): 735 – 744. Ogunniran KO, Tella AC, Alensa M and Yakubu MT 2007. Synthesis, physical properties, antimicrobial potentials of some antibiotics complexed with transition metals and their effects on alkaline phosphastase activities of selected rat tissues.Afr. J. Biotechn., 6(10): 1202-1208. Reddy KK, Rao S & Rao BS 2015. Synthesis and characterization and biological activities of hydrazones.Int. J. Innov. Res. Sci. Eng. Techno.,4(1): 18944-18952. Roman L & Chundak S 2014.Synthesis, structure, and characteristic of Zn(II) andCd(II) coordination compounds with 3-methoxybenzeneacid hydrazide and their biological activity. Chem. Technol.,8(2): 123-128. Salawu OW, Eneji IS & Salami HA 2015. Preparation and spectroscopic characterization of 2-ethoxy isobutryl acid hydrazide and 2-ethoxy isobutrylaceto hydrazone and its metal complexes with Co(II), Ni(II) and Cu(II). Int. J. Inorg. Bioinorg. Chem., 5(2): 23-27. Sule I & Nwabueze JN 2013. Complexes of copper (II) with some hydrazones derived from nicotinic and isonicotinic acid hydrazides.Int. J. Inorganic & Bioinorg. Chem., 3(3): 52-56.